Endocrine Abstracts

Introduction: SIADH is frequently observed as a paraneoplastic secretion in many cancer types with the highest frequency described in small-cell lung cancer. The paraneoplastic secretion of ADH/vasopressin may induce hyponatraemia which is associated with increased morbidity and mortality. Conventional treatment of the condition consists of fluid restriction and demeclocycline. Tolvaptan, an oral V2-receptor antagonist, that directly targets the mechanism of SIADH, has been pr...

Introduction: Prolactinomas account for approximately 40% of all pituitary adenomas, with an estimated prevalence of 100 prolactinomas per million adults. Dopamine agonists currently represent the mainstay of treatment. Nevertheless, increasing dopamine-agonist dosage, surgery, and radiotherapy may be necessary in some cases, such as aggressive, dopamine-agonist resistant or atypical prolactinomas.Case: We report the case of a 55 year old man who was inc...

Background: Diabetes is the commonest cause of ketoacidosis, with alcoholic and starvation ketoacidosis encountered less frequently. We present a case of high anion gap metabolic acidosis whose features were not categorigal for usual causes.Case presentation: A 42-year-old female patient was admitted with a 3 day history of nausea, vomiting and abdominal pain, that begun 1 day after binge alcohol intake, on the background of alcohol excess. AKI, transami...

Aim: To find out all Acromegalic patients above the age of 40 years had their colonoscopic screening or not.Reason for colonoscopy screening: There is 13 to 14 fold increased risk of colorectal cancer in Acromegaly patients and 2.5 fold increase in mortality from Colonic cancer.Standards: i) Patientts with acromegaly should be offered regular colonoscopy from the age of 40 years.ii) ...

Introduction: Hyperparathyroidism is uncommon during pregnancy with less than 200 cases reported worldwide. Untreated, this condition can result in a 20–30% incidence of fetal death and 50–60% incidence of complications during pregnancy. If recognized early, the condition is treatable with significant improvement in fetal and maternal outcomes.Case: We report the case of 35-year-old asymptomatic Asian female (gravida 9 para 4, one stillbirth) w...

Insulinoma is a rare but potentially treatable cause of hypoglycaemia. We present a case where achieving a diagnosis of insulinoma was complicated by evidence of low serum insulin levels during documented biochemical hypoglycaemia.A 58 year old lady presented with weight gain and daily episodes of shaking, hot flushes and disorientation that were relieved by the ingestion of food. During symptomatic episodes home capillary blood glucose measurements sugg...

Patients and methods: 190 acromegalic patients are registered in the National Diabetes Center, 60 were enrolled in the study. They were randomly selected by simple sampling technique according to their scheduled visits monthly to receive - long acting repeatable octreotide injections (LAR).Results: Table 1 Demographic data of the enrolled acromegalic patients.</c...

The sequence of pituitary growth hormone (GH) is generally strongly conserved in mammals, but short bursts of rapid change during the evolution of primates and artiodactyls have led to marked differences in primary structure and biological specificity in human and ruminant GHs. Recent molecular studies have shown that Cetacea are nested within Artiodactyla, and the combined grouping (Artiodactyla and Cetacea) has been termed the Cetartiodactyla. To explore further GH evolution...

Purpose: To determine the changes of the choroidal thickness (CT) in diabetes mellitus (DM) type 1 patients without clinical diabetic retinopathy (DR).Methods: We evaulated 50 patients with DM type 1 (50 eyes) and 50 healthy controls (50 eyes) in İzmir Military Hospital from January 2012, through January 2013. DR status was evaluated by indirect fundoscopy and included the study if they have no clinical diabetic retinopathy. Age, gender, duration s...

Introduction and aim: Congenital adrenal hyperplasia (CAH) is rare autosomal recessive disease. CAH due to 21-hydroxylase deficiency accounts for 95% of cases. We aim to define in this report 59-year-old woman with simple virilizing type CAH who diagnosed granulosa cell tumour and I172N mutation in the CYP21A as well as triple translocation involving chromosome 9p, 11p and 12p at first time in the literature.Case report: A 59-year-old woman was applied t...